Induced pluripotent stem cells — opportunities for disease modelling and drug discovery
Identifieur interne : 000285 ( Main/Exploration ); précédent : 000284; suivant : 000286Induced pluripotent stem cells — opportunities for disease modelling and drug discovery
Auteurs : Marica Grskovic [États-Unis] ; Ashkan Javaherian [États-Unis] ; Berta Strulovici [Israël] ; George Q. Daley [États-Unis]Source :
- Nature Reviews Drug Discovery [ 1474-1776 ] ; 2011-12.
Abstract
The ability to generate induced pluripotent stem cells (iPSCs) from patients, and an increasingly refined capacity to differentiate these iPSCs into disease-relevant cell types, promises a new paradigm in drug development — one that positions human disease pathophysiology at the core of preclinical drug discovery. Disease models derived from iPSCs that manifest cellular disease phenotypes have been established for several monogenic diseases, but iPSCs can likewise be used for phenotype-based drug screens in complex diseases for which the underlying genetic mechanism is unknown. Here, we highlight recent advances as well as limitations in the use of iPSC technology for modelling a 'disease in a dish' and for testing compounds against human disease phenotypes in vitro. We discuss how iPSCs are being exploited to illuminate disease pathophysiology, identify novel drug targets and enhance the probability of clinical success of new drugs.
Url:
DOI: 10.1038/nrd3577
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Induced pluripotent stem cells — opportunities for disease modelling and drug discovery</title><author><name sortKey="Grskovic, Marica" sort="Grskovic, Marica" uniqKey="Grskovic M" first="Marica" last="Grskovic">Marica Grskovic</name></author><author><name sortKey="Javaherian, Ashkan" sort="Javaherian, Ashkan" uniqKey="Javaherian A" first="Ashkan" last="Javaherian">Ashkan Javaherian</name></author><author><name sortKey="Strulovici, Berta" sort="Strulovici, Berta" uniqKey="Strulovici B" first="Berta" last="Strulovici">Berta Strulovici</name></author><author><name sortKey="Daley, George Q" sort="Daley, George Q" uniqKey="Daley G" first="George Q." last="Daley">George Q. Daley</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:57B2D0EFAAD0CCE639D0D91C72732E7DC7E190E5</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1038/nrd3577</idno><idno type="url">https://api.istex.fr/document/57B2D0EFAAD0CCE639D0D91C72732E7DC7E190E5/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001280</idno><idno type="wicri:Area/Main/Curation">001075</idno><idno type="wicri:Area/Main/Exploration">000285</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Induced pluripotent stem cells — opportunities for disease modelling and drug discovery</title><author><name sortKey="Grskovic, Marica" sort="Grskovic, Marica" uniqKey="Grskovic M" first="Marica" last="Grskovic">Marica Grskovic</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>iPierian, 951 Gateway Blvd, South San Francisco, California 94080</wicri:regionArea><wicri:noRegion>California 94080</wicri:noRegion></affiliation><affiliation><wicri:noCountry code="no comma">These authors contributed equally to this work.</wicri:noCountry></affiliation></author><author><name sortKey="Javaherian, Ashkan" sort="Javaherian, Ashkan" uniqKey="Javaherian A" first="Ashkan" last="Javaherian">Ashkan Javaherian</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>iPierian, 951 Gateway Blvd, South San Francisco, California 94080</wicri:regionArea><wicri:noRegion>California 94080</wicri:noRegion></affiliation><affiliation><wicri:noCountry code="no comma">These authors contributed equally to this work.</wicri:noCountry></affiliation></author><author><name sortKey="Strulovici, Berta" sort="Strulovici, Berta" uniqKey="Strulovici B" first="Berta" last="Strulovici">Berta Strulovici</name><affiliation wicri:level="1"><country xml:lang="fr">Israël</country><wicri:regionArea>Weizmann Institute of Science, Rehovot 76100</wicri:regionArea><wicri:noRegion>Rehovot 76100</wicri:noRegion></affiliation></author><author><name sortKey="Daley, George Q" sort="Daley, George Q" uniqKey="Daley G" first="George Q." last="Daley">George Q. Daley</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Stem Cell Transplantation Program, Division of Pediatric Haematology/Oncology, Manton Center for Orphan Disease Research, Children's Hospital Boston and Dana Farber Cancer Institute; Boston, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Howard Hughes Medical Institute, Chevy Chase, Maryland 20815</wicri:regionArea><wicri:noRegion>Maryland 20815</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Division of Hematology, Brigham and Women's Hospital; Boston, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Biological Chemistry and Molecular Pharmacology, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115</wicri:regionArea><wicri:noRegion>Massachusetts 02115</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142</wicri:regionArea><wicri:noRegion>Massachusetts 02142</wicri:noRegion></affiliation><affiliation><wicri:noCountry code="no comma">These authors contributed equally to this work.</wicri:noCountry></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Nature Reviews Drug Discovery</title><idno type="ISSN">1474-1776</idno><idno type="eISSN">1474-1784</idno><imprint><publisher>Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</publisher><date type="published" when="2011-12">2011-12</date><biblScope unit="volume">10</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="915">915</biblScope><biblScope unit="page" to="929">929</biblScope></imprint><idno type="ISSN">1474-1776</idno></series><idno type="istex">57B2D0EFAAD0CCE639D0D91C72732E7DC7E190E5</idno><idno type="DOI">10.1038/nrd3577</idno><idno type="ArticleID">nrd3577</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1474-1776</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">The ability to generate induced pluripotent stem cells (iPSCs) from patients, and an increasingly refined capacity to differentiate these iPSCs into disease-relevant cell types, promises a new paradigm in drug development — one that positions human disease pathophysiology at the core of preclinical drug discovery. Disease models derived from iPSCs that manifest cellular disease phenotypes have been established for several monogenic diseases, but iPSCs can likewise be used for phenotype-based drug screens in complex diseases for which the underlying genetic mechanism is unknown. Here, we highlight recent advances as well as limitations in the use of iPSC technology for modelling a 'disease in a dish' and for testing compounds against human disease phenotypes in vitro. We discuss how iPSCs are being exploited to illuminate disease pathophysiology, identify novel drug targets and enhance the probability of clinical success of new drugs.</div></front></TEI><affiliations><list><country><li>Israël</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Grskovic, Marica" sort="Grskovic, Marica" uniqKey="Grskovic M" first="Marica" last="Grskovic">Marica Grskovic</name></noRegion><name sortKey="Daley, George Q" sort="Daley, George Q" uniqKey="Daley G" first="George Q." last="Daley">George Q. Daley</name><name sortKey="Daley, George Q" sort="Daley, George Q" uniqKey="Daley G" first="George Q." last="Daley">George Q. Daley</name><name sortKey="Daley, George Q" sort="Daley, George Q" uniqKey="Daley G" first="George Q." last="Daley">George Q. Daley</name><name sortKey="Daley, George Q" sort="Daley, George Q" uniqKey="Daley G" first="George Q." last="Daley">George Q. Daley</name><name sortKey="Daley, George Q" sort="Daley, George Q" uniqKey="Daley G" first="George Q." last="Daley">George Q. Daley</name><name sortKey="Daley, George Q" sort="Daley, George Q" uniqKey="Daley G" first="George Q." last="Daley">George Q. Daley</name><name sortKey="Javaherian, Ashkan" sort="Javaherian, Ashkan" uniqKey="Javaherian A" first="Ashkan" last="Javaherian">Ashkan Javaherian</name></country><country name="Israël"><noRegion><name sortKey="Strulovici, Berta" sort="Strulovici, Berta" uniqKey="Strulovici B" first="Berta" last="Strulovici">Berta Strulovici</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000285 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000285 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:57B2D0EFAAD0CCE639D0D91C72732E7DC7E190E5
|texte= Induced pluripotent stem cells — opportunities for disease modelling and drug discovery
}}
| This area was generated with Dilib version V0.6.23. |  |